姓名：金贵善 性别：女 职称：教授
招生类型：科学学位(硕) 科学学位(博)
招生专业：外科学（神外）(硕) 外科学（神外）(博)
研究方向：脑胶质瘤发生机制及生物学治疗研究
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社会任职
个人简历
重要学术论文
1. Junwen Zhang, Jialin Wang, Mingxin Li, Xiaodong Su, Yifu Tian, Peiwen Wang, Xianzhe Zhou, Guishan Jin, Fusheng Liu*.Oncolytic HSV-1 suppresses cell invasion through downregulating Sp1 in experimental glioblastoma.Cellular Signalling.2023.103.110581.SCI
2. Xiangming Han, Qiyan Wang, Sheng Fang, Jialin Wang, Fusheng Liu, Junwen Zhang* and Guishan Jin*.P4HA1 regulates CD31 via COL6A1 in the transition of glioblastoma stem-like cells to tumor endothelioid cells.Frontiers in Oncology.2022.12.836511.SCI
3. Guidong Zhu, Junwen Zhang, Qing Zhang, Guishan Jin, Xiaodong Su, Sisi Liu, Fusheng Liu*.Enhancement of CD70?specific CAR T treatment by IFN?γ releasedfrom oHSV?1?infected glioblastoma.Cancer Immunology, Immunotherapy.2022.71（10）.2433-2448.SCI
4. Qing Zhang, Junwen Zhang, Peiwen Wang, Guidong Zhu, Guishan Jin and Fusheng Liu*.Glioma?associated mesenchymal stem cells?mediated PD?L1 expression is attenuated by Ad5?Ki67/IL?15 in GBM treatment.Stem Cell Research & Therapy.2022.13.284.SCI
5. Xiaodong Su#, Yuan Xie#, Junwen Zhang, Mingxin Li, Qing Zhang, Guishan Jin and Fusheng Liu*.HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis.Cell Death and Disease.2022.13.861.SCI
6. Qiyan Wang, Junwen Zhang*, Sheng Fang, Jialin Wang, Xiangming Han, Fusheng Liu* and Guishan Jin*.P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization.OncoTargets and Therapy.2021.14.1771-1782.SCI
7. Junwen Zhang#, Sheng Fang#, Wenjie Song, Bo Zhang, Wenhua Fan, Guishan Jin, Fusheng Liu*.Biological Characterization and Therapeutics for Subscalp Recurrent in Intracranial Glioblastoma.OncoTargets and Therapy.2020.13.9085-9099.SCI
8. 张梦梦，张俊文，米蕊芳，金贵善，刘福生*.siRNA干扰BTN3A3对脑胶质瘤细胞凋亡作用的研究.中华神经外科杂志.2020.36（9）.951-956.核心期刊
9. 方胜, 张俊文, 董程远, 田毅夫, 王启俨, 刘福生, 金贵善*.P4HA1调控EMT影响脑胶质瘤侵袭性研究.中国科学: 生命科学.2020.50（4）.446-457.核心期刊
10. Ruifang Mi, Wenhua Fan, Jiayu Ji, Chengyuan Dong, Guishan Jin, Fusheng Liu*.The enhanced efficacy of herpes simplex virus by lentivirus mediated VP22 and cytosine deaminase gene therapy against glioma.Brain Research.2020.1743.146898（1-9）.SCI
11. Bo Zhang#, Junwen Zhang#, Sheng Fang, Mengmeng Zhang, Sisi Liu, Yifu Tian, Mengjiao Ma, Fusheng Liu, Guishan Jin*.Inflammatory activation of microglia by Staphylococcus aureus caused phenotypic alterations and affected glioblastoma growth.Cell Biochem Funct.2019.1-9.DOI: 10.1002/cbf.3396.SCI
12. Wenhua Fan, Meiyu Shao, Junwen Zhang, Guishan Jin, Fu-Jian Xu,* and Fusheng Liu*.A Hybrid nanovector of suicide gene engineered lentivirus coated with bioreducible polyaminoglycosides for enhancing therapeutic efficacy against glioma.Adv. Funct. Mater..2019.29.1807104.SCI
13. 张昀昇，张俊文，米蕊芳，周益强，程森，宋文杰，刘福生，金贵善*.TRIM33对人脑胶质瘤U251细胞生物学功能影响的实验研究.中华神经外科杂志.2018.34（3）.292-298.核心期刊
14. Yunsheng Zhang#, Guishan Jin#, Junwen Zhang, Ruifang Mi, Yiqiang Zhou, Wenhua Fan, Sen Cheng, Wenjie Song, Bo Zhang, Mengjiao Ma, Fusheng Liu*.Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF?A in human glioma cells.Biomedicine & Pharmacotherapy.2018.104.566-575.SCI
15. 张俊文，丛晓杰，赵乔佳杰，杨霞，李梦，陈虹，米蕊芳，金贵善，黄秉仁，刘福生*.RanBPM结合干扰素γ信号通路中的干扰素受体1.中国科学 生命科学.2017.47（7）.718-727.核心期刊
16. Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F*.Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane.Oncotarget.2017.8（22）.35877-35889.SCI
17. Sen Cheng#,Ruifang Mi #, Yu Xu,Guishan Jin,Junwen Zhang, Yiqiang Zhou,Zhengguang Chen, Fusheng Liu*.Ferritin heavy chain as a molecular imaging reporter gene in glioma xenografts.J Cancer Res Clin Oncol .2017.143（6）.941-951.SCI
18. 徐恒周，金贵善，米蕊芳，张俊文，周益强，刘福生*.FASN在脑胶质瘤组织中的表达及其临床意义.中华神经医学杂志.2017.16（3）.217-221.核心期刊
19. 米蕊芳，金贵善，张俊文，周益强，徐恒周，程森，刘福生.VP22-CD基因工程化载体对胶质瘤细胞体外杀伤作用的研究.中华神经外科杂志.2016.6（32）.614-618.核心期刊
20. Mi RF, Pan CX, Zhou YQ, Liu YB, Jin GS*, Liu FS*.Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method.Oncology reports.2016.35(1).211-218.SCI
21. 金贵善，刘福生*.医学硕士研究生创新能力培养的分析和思考.医学教育管理.2016.2（supp2）.118-120.核心期刊
22. 刘福生，金贵善*.对医学专业学位硕士研究生科研能力培养的思考与体会.医学教育管理 .2016.2（2）.438-440.核心期刊
23. 米蕊芳，潘春晓，刘福生，张俊文，金贵善*.荧光探针及流式分选法追踪胰腺癌细胞增殖的研究.医学研究杂志.2016.45（5）.29-32.核心期刊
24. Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F*.Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma.J Cancer Res Clin Oncol.2016.142.2447-2459.SCI
25. 米蕊芳，金贵善，张俊文，周益强，徐恒周，程森，刘福生*.人胶质瘤自杀基因细胞系的建立及其在胶质瘤治疗研究中的应用.医学研究杂志.2016.45（5）.46-49.核心期刊
26. 张晋，金贵善，米蕊芳，周益强，房绍伟，刘福生*.神经胶质瘤干细胞向内皮细胞分化的差异基因表达谱的分析.中华神经外科杂志.2015.31（3）.299-303.核心期刊
27. Dong C#, Mi R#, Jin G, Zhou Y, Zhang J, Liu F.Identification of the proliferative effect of Smad2 and Smad3 in TGFβ2/Smads signal pathway using RNA interference in glioma cell line.Molecular Medicine Reports.2015.12.1824-1828.SCI
28. 董程远，金贵善，米蕊芳，周益强，张晋，刘福生*.shRNA干扰技术对脑胶质瘤细胞中TGFβ2/Smads通路的研究.中华神经外科杂志.2014.30(4).404-408.核心期刊
29. 周益强，金贵善 米蕊芳 董程远 张晋 刘福生*.血小板源性生长因子B及其基因启动子区甲基化在脑胶质瘤中的表达及意义.中华神经外科杂志 .2014.30(3).288-291.核心期刊
30. 聂秀涛，金贵善，徐厚池，刘福生*.脑胶质瘤干细胞和血管关系的研究进展.中华神经外科杂志.2014.30(3).315-317.核心期刊
31. Zhang GB, Jin GS, Nie XT, Mi RF, Zhu Guidong, Liu FS*.Enhanced antitumor efficacy of an oncolytic herpes simplex virus expressing an endostatin-angiostatin fusion gene in human glioblastomas stem cell xenografts.PLOS ONE.2014.9（4）.e95872.SCI
32. Zhou YQ#, Jin GS#, Mi RF, Dong CY, Zhang J, Liu FS*.The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells.Brain Research.2014.1556.57-66.SCI
33. 张国滨，金贵善，米蕊芳，周益强，董程远，刘福生*.内皮抑素和血管生成抑素融合基因修饰的单纯疱疹病毒对胶质瘤干细胞杀伤作用的实验研究.中华神经外科杂志.2014.30（7）.723-728.核心期刊
34. 周益强，金贵善，刘福生.PDGF-B在脑胶质瘤中的研究进展.中华神经外科杂志.2014.30（8）.844-846.核心期刊
35. 米蕊芳，刘福生，金贵善*.多核巨细胞对小鼠黑色素瘤细胞转移能力的研究.中华临床医师杂志.2013.7(14).6457-6461.核心期刊
36. 聂秀涛，金贵善，米蕊芳，张国滨，谢坚，曹泽，周益强，董程远，刘福生*.人脑胶质瘤干细胞分化为血管内皮细胞的实验研究.中华神经外科杂志.2013.29（3）.289-293.核心期刊
37. Jin GS, Zhou YQ, Chai Q, Zhu GT, Xu FJ, Liu FS*.VP22 and cytosine deaminase fusion gene modified tissue-engineered neural stem cells for glioma therapy.J Canc Res Clin Oncol.2013.139 (3).475-483.SCI
38. Jin GS, Hao SY, Xie J, Mi RF and Liu FS*.Collision tumors of the sella: coexistence of pituitary adenoma and craniopharyngioma in the sellar region.World journal of surgical Oncology.2013.11.178（1-7）.SCI
39. 米蕊芳，刘福生，金贵善*.植物血凝素-ECM830细胞融合法融合黑色素瘤细胞.中国医学科学院学报.2013.35（5）.515-518.核心期刊
40. Jin GS, Zhu GD, Zhao ZG, Liu FS*.VP22 enhances the expression of gluco-cerebrosidase in human Gauche II fibroblast cells mediated by lentivirus vector.Clin Exp Med.2012.12(3).135-143.SCI
41. 刘福生，金贵善*.指导临床医学科研型硕士研究生发表SCI论文.首都医科大学学报社科版.2012.增刊.355-357.核心期刊
42. 曹泽、金贵善、刘福生*、谢坚.TGF-β2/Smad2 在人脑胶质瘤组织中的表达及意义.中华临床医师杂志.2012.6（6）.43-46.核心期刊
43. 金贵善，刘福生*.培养科研型硕士研究生的科研思维.首都医科大学学报社科版.2012.增刊.353-354.核心期刊
44. Zhu GD, Su W，Jin GS, Xu FJ, Hao SY, Guan FX, Jia W, Liu FS*.Glioma stem cells targeted by oncolytic virus carrying endostatin-angiostatin fusion gene and the expression of its exogenous gene in vitro.Brain Research.2011.1390.59-69.SCI
45. 苏伟，朱贵东，刘福生*，姜中利，金贵善，柴奇，曹泽，聂秀涛.Smad2基因在人脑胶质瘤的表达及其临床意义.中华神经外科杂志.2011.27（10）.1064-1068.核心期刊
46. 苏伟，刘福生*，朱贵东，姜中利，金贵善，柴奇，曹泽.人脑胶质瘤中转化生长因子β2、Smad3蛋白表达及临床意义.中国康复理论与实践.2011.17（5）.433-436.核心期刊
47. 朱贵东，刘福生*，苏伟，金贵善，柴奇.内皮抑素和血管生成抑素融合基因修饰的单纯疱疹病毒对胶质瘤干细胞的体外实验研究.中华神经外科杂志.2011.27（9）.949-954.核心期刊
48. 金贵善, 刘福生* ,柴奇, 苏伟 ,朱贵东.VP22修饰的CD基因工程化干细胞治疗大鼠C6脑胶质瘤体外实验研究.中华神经外科杂志.2009.25(11).1039-1043.核心期刊
49. 金贵善，刘福生*，柴奇，苏伟，朱贵东.慢病毒载体VP22-EGFP的构建及其对大鼠神经干细胞转染及表达的研究.中华神经外科杂志.2009.25 (3).278-282.核心期刊
50. Jin GS, Liu FS*, Chai Q, Wang JJ, Li JH.Stable EGFP gene expression in C6 glioma cell line after transduction with HIV-based lentiviral vector.Chin J Cancer Res.2008.20.243-248.SCI
51. 王建交，杨立庄，刘福生* ，金贵善， 柴奇.内皮抑素和血管生成抑素融合基因的裂解病毒对C6胶质瘤的实验研究.中华神经外科杂志.2008.24（1）.69-72.核心期刊
52. Jin GS, Liu FS*, Chai Q, Li JH.Fusions of dendritic cells transfected with TGF-β1 antisense in treatment of intracranial gliomas.Chin J Cancer Res.2007.19.113-118.SCI
53. 金贵善，刘福生*，柴奇，王建交，车树圣.慢病毒介导的稳定表达绿色荧光蛋白的C6胶质瘤细胞株的建立及其生物学特性的观察.中华神经外科杂志.2007.23.541-544.核心期刊
主编或副主编的著作/译著
1. 《脑胶质瘤基础与临床研究》,主编,人民卫生出版社,201603
重要奖项
1. 脑胶质瘤化学治疗和生物治疗的研究 山东省科学技术进步奖 二等奖 2013
2. 脑胶质瘤化学治疗和生物治疗的实验研究 华夏医学科技奖 三等奖 2012
