姓名：张亚卓 性别：男 职称：教授
招生类型：科学与专业学位(硕) 科学与专业学位(博)
招生专业：外科学（神外）(硕) 外科学（神外）(博)
研究方向：垂体瘤与颅底脊索瘤的基础与临床研究
电子信箱：zyzxizxg@public.bta.net.cn
社会任职
1. 中国医师协会神经内镜医师培训学院院长
2. 中国医师协会内镜医师分会神经内镜专家委员会主任委员
3. 北京医学会神经外科分会主任委员
4. 中国医师协会神经修复学专业委员会主任委员
5. 首都医科大学垂体腺瘤临床诊疗与研究中心主任
6. 中国医师协会内镜医师分会副会长
7. 《中华神经外科杂志》总编辑
8. 世界华人神经外科协会第三届委员会主席
9. 北京市脑重大疾病研究院脑肿瘤研究所所长
个人简历
1. 199704- :北京市神经外科研究所 北京天坛医院神经外科 主任医师
2. 199507-199704:北京市神经外科研究所 博士后 副主任医师
3. 199208-199507:天津医科大学总医院神经外科 攻读博士学位
4. 198908-199208:佳木斯医学院附属医院神经外科 主治医师
5. 198608-198908:天津医科大学总医院 攻读硕士学位 主治医师
6. 198208-198608:佳木斯医学院附属医院神经外科 住院医师
7. 197803-198208:佳木斯医学院医疗系 大学本科
重要学术论文
1. Jing Guo#,Chuzhong Li#,Qiuyue Fang,Yulou Liu,Dawei Wang,Yiyuan Chen,Weiyan Xie*，Yazhuo Zhang*.The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.Journal Of Experimental & Clinical Cancer Research.2022.41（1）.26.SCI
2. Jiwei Bai#, Jianxin Shi#, Chuzhong Li #, Shuai Wang#, Tongwu Zhang , Xing Hua, Bin Zhu , Hela Koka, Ho-Hsiang Wu , Lei Song, Difei Wang, Mingyi Wang , Weiyin Zhou,Bari J. Ballew, Bin Zhu, Belynda Hicks , Lisa Mirabello, Dilys M. Parry, Yixuan Zhai, Mingxuan Li, Jiang Du, Junmei Wang, Shuheng Zhang, .Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival.nature communications.2021.12（1）.757.SCI
3. Chuzhong Li#,Weiyan Xie#, Jared S. Rosenblum,Jianyu Zhou, Jing Guo, Yazhou Miao, Yutao Shen, Hongyun Wang, Lei Gong, Mingxuan Li,Sida Zhao, Sen Cheng, Haibo Zhu,Tao Jiang, Shiying Ling, Fei Wang, Hongwei Zhang,Zhengping Zhuang*, Yazhuo Zhang*.Somatic SF3B1 hotspot mutation in prolactinomas .Nature Communications.2021.11(1).2506.SCI
4. Mingxuan Li,Yutao Shen,Yujia Xiong ,Shuai Wang,Chuzhong Li ,Jiwei Bai *,Yazhuo Zhang *.Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.Cell Proliferation.2021.54(12).13136.SCI
5. Jiwei Bai,Mingxuan Li,Yujia Xiong,Yutao Shen,Chunhui Liu, Peng Zhao, Lei Cao,Songbai Gui,Chuzhong Li*, Yazhuo Zhang*.Proteomics Analysis Identified ASNS as a Novel Biomarker for Predicting Recurrence of Skull Base Chordoma.frontiers in oncology.2021.11.698497.SCI
6. Song G, Qiu J, Li C, Li J, Gui S, Zhu H, Zhang Y*.Alterations of regional homogeneity and functional connectivity in pituitary adenoma patients with visual impairment.Scientific Reports.2017.7(1).-.SCI
7. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI
8. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI
9. Weiyan Xie#，Chunhui Liu，Dan Wu, Zhenye Li, Chuzhong Li， and Yazhuo Zhang*.Phosphorylation of kinase insert domain receptor by cyclindependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas.Oncotarget.2016.7.50883-50894.SCI
10. YOUTU WU#, JIWEI BAI, LINCHUAN HONG, CHUNHUI LIU, SHENGYUAN YU, GUOQIANG YU and YAZHUO ZHANG*.Low expression of secreted frizzled.related protein 2 and nuclear accumulation of β.catenin in aggressive nonfunctioning pituitary adenoma.ONCOLOGY REPORTS.2016.12.199-206.SCI
11. Youtu Wu#, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li and Yazhuo Zhang*.Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas.ONCOLOGY REPORTS.2016.35.2991-2999.SCI
12. Chunhui Liu＃, Hua Gao＃, Lei Cao, Songbai Gui, Qian Liu, Chuzhong Li, Dan Li, Lei Gong, and Yazhuo Zhang＊.The Role of FSCN1 in Migration and Invasion of Pituitary Adenomas.Mol Cell Endocrinol..2016.419.217-24.SCI
13. Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui,Lichuan Hong and Yazhuo Zhang＊.Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. .BMC TUMOR.2015.15(1).272.SCI
14. Wu Y, Bai J, Li Z, Wang F, Cao L, Liu C, Yu S, Yu G, Zhang Y*.Low expression of secreted frizzled-related protein 4 in aggressive pituitary adenoma.Pituitary.2015.18(3).335-42.SCI
15. Li Z, Liu Q, Li C, Zong X, Bai J, Wu Y, Lan X, Yu G, Zhang Y*.The role of TGF-β/Smad signaling in dopamine agonist-resistant prolactinomas.molecular and cellular endocrinology.2015.402.64-71.SCI
16. Xie W, Wang H, He Y, Li D, Gong L, Zhang Y*.CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression.Int J Biol Sci.2014.10(2).192-199. .SCI
17. Cao L, Gao H, Gui S, Bai G, Lu R, Wang F, Zhang Y*.Effects of the estrogen receptor antagonist fulvestrant on F344 rat prolactinoma models.J Neurooncol.2014.116(3).523-531.SCI
18. Hong L, Wu Y, Feng J, Yu S, Li C, Wu Y, Li Z, Cao L, Wang F, Zhang Y*.Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.human pathology.2014.45（12）.2423-2429.SCI
19. Zhenye L, Chuzhong L, Youtu W, Xiaolei L, Lei C, Lichuan H, Hongyun W, Yonggang W, Fei W, Yazhuo Z*.The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas.journal of translational medicine.2014.12.71.SCI
20. 姜之全，桂松柏，张亚卓*.Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays.J Neurooncol.2012.108（3）.341-348.SCI
21. 张亚卓 .建立转化医学平台、促进神经外科人才培养 .中华神经外科杂志.2010.26（11）.961-962.核心期刊
22. 裴傲; 张亚卓*; 宗绪毅; 王新生; 赵澎; 宋明;.内镜经鼻蝶入路手术治疗大型垂体腺瘤. 中国神经肿瘤杂志.2009.7(1).22-24.
23. 刘方军; 张亚卓; 赵澎; 张永力; 孙玉明; 周忠清; 王计强; 石祥恩;.颅内血管外膜细胞瘤的临床诊治6例分析及文献复习 . 中国神经肿瘤杂志.2009.7（2).118-121.
24. 李储忠; 赵澎; 宗绪毅; 桂松柏; 刘方军; 张亚卓*.单鼻孔内镜下经蝶、扩大经蝶入路肿瘤切除术术中、术后出血原因分析及对策 .中国神经肿瘤杂志 .2009.7（1).33-36.
25. 李储忠; 张亚卓*.神经内镜应用进展 .中国神经精神疾病杂志.2009.35（2）.67—68.
26. 桂松柏; 张亚卓*; 王新生; 宗绪毅; 赵澎;.内镜颅底手术后颅内感染的综合治疗1例报告 .中国神经肿瘤杂志 .2009.7（1).37-38.
27. 宋明1， 张亚卓2*.内镜技术在中枢神经系统肿瘤治疗中的应用.中国神经肿瘤杂志.2009.7(1).1-5.
28. 赵澎1， 桂松柏1， 李储忠1， 宋明2， 裴傲3， 王新生1， 宗绪毅1， 张亚卓*.神经内镜治疗脑室内肿瘤20 例临床经验.中国神经肿瘤杂志.2009.7(1).7-13.
29. 桂松柏，张亚卓*孙梅珍.氧化损伤星形胶质细胞与骨髓基质细胞共培养的实验研究 .中华神经医学杂志 .2008.7（3）.267-272.
30. 赵澎，张亚卓*.Reversion of nultidrug resistance in human glioma by RNA interference .Neurological Research.2008.30.562~566.
31. 严耀华，张亚卓*.三脑室底造瘘中的心率变化.中华神经外科杂志.2008.24(3).193-195.
32. 宋明，张亚卓*，王新生，宗绪毅.内镜下经鼻入路显露视神经和眼眶的解剖研究.中国内镜杂志.2008.14(4).357-360.
33. 刘方军，张亚卓*，桂松柏，孙泽林.F90对胶质母细胞瘤的作用及机制研究.中国微侵袭神经外科杂志.2008.13(5).220-222.
主编或副主编的著作/译著
1. 《内镜神经外科学（第3版）》,主编,人民卫生出版社,202211
2. 《神经内镜手术规范化培训教程》,主编,人民卫生出版社,201804
3. 《内镜神经外科学（第2版）》,主编,人民卫生出版社,201705
4. 《内镜神经外科学》,主编,人民卫生出版社,201207
5. 《《脑室外科学》》,主编,人民卫生出版社,201101
6. 《内镜颅底外科(翻译版)》,主译,科学出版社,201003
7. 《神经内镜手术技术》,主编,北京大学医学出版社,200403
8. 《脑室外科手术学》,主编,中国协和医科大学出版社,200110
重要奖项
1. 颅底内镜技术研发转化与应用 北京市科技进步二等奖 2012
2. 微侵袭神经内镜应用技术的研究 市三等（1） 2003
3. 微侵袭内镜神经外科应用技术研究 中华医学奖三等 2003
4. 微侵袭内镜神经外科应用技术研究 北京市科技技术奖三等奖 2003
5. 脑干肿瘤的基础与临床研究 市二等 2000
